Table of Contents

Preface (D.F. Williams)Controlled release of biologically active compounds from bioerodible polymers (J. Heller)The response to the intramuscular implantation of pure metals (A. McNamara and D.F. Williams)Osseointegrated titanium fixtures in the treatment of edentulousness (P.I. Branemark, R. Adell, T. Albrektsson, U. Lekholm, S. Lundkvist and B. Rockler)Biomaterial biocompatibility and the macrophage (J.M. Anderson and K.M. Miller)Systematic effects of biomaterials (J. Black)The in vitro response of osteoblasts to bioactive glass (T. Matsuda and J.E. Davies)Activtion of the complement system at the interface between blood and artificial surfaces (M.D. Kazatchkine and M.P. Carreno)Dynamic and equilibrium swelling behaviour of pH-sensitive hydrogels containing 2-hydroxyethyl methacrylate (L. Brannon-Peppas and N.A. Peppas)Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution (P. Aebischer, L. Wahlberg, P.A. Tresco and S.R. Winn)Interaction between phospholipids and biocompatible polymers containing a phosphorylcholine moiety )M. Kojima, K. Ishihara, A. Watanabe and N. Nakabayashi)Quantitative assessment of the tissue response to implanted biomaterials (D.G. Vince, J.A. Hunt and D.F. Williams)Immune response in biocompatibility (A. Remes and D.F. Williams)Laminated three-dimensional biodegradable foams for use in tissue engineering (A.G. Mikos, G. Sarakinos, S.M. Leite, J.P. Vacanti and R. Langer)Late degradation tissue response to poly(L-lactide) bone plates and screws (J.E. Bergsma, W.C. de Bruijn, F.R. Rozema, R.R. Bos and G. Boering)Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces (T. Okano, N. Yamada, M. Okuhara, H. Sakai and Y. Sakurai)Mechanisms of polymer degradation and erosion (A. Gopferich)Stabilized polyglycolic acid fibre-based tubes for tissue engineering (D.J. Mooney, C.L. Mazzoni, C. Breuer, K. McNamara, D. Hern, J.P. Vacanti, et al)Poly(alpha-hydroxy acids): carriers for bone morphogenetic proteins (J.O. Hollinger and K. Leong)Response of MG63 osteoblast-like cells to titanium and titaniun alloy is dependent on surface roughness and composition (J. Lincks, B.D. Boyan, C.R. Blanchard, C.H. Lohmann, Y. Liu, D.L. Cochran, et al)Patterning proteins and cells using soft lithography (R.S. Kane, S. Takayama, E. Ostuni, D.E. Ingber and G.M. Whitesides)Scaffolds in tissue engineering bone and cartilage (D.W. Hutmacher)Topographical contol of human neutrophil motility on micropatterned materials with various surface chemistry (J. Tan and W.M. Saltzman)Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks (Y.D. Park, N. Tirelli and J.A. Hubbell)Cell sheert engineering for myocardial tissue reconstruction (T. Shimizu, M. Yamato, A. Kikuchi and T. Okano)Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes (M.B. Gorbet and M.V. Sefton)Author Index

About the Author

Professor Williams has had 48 years experience in biomaterials, medical device and tissue engineering, working mostly at the University of Liverpool, UK where he was ultimately Professor of Biomaterials and Biomedical Engineering, Director of the UK Centre for Tissue Engineering and Senior Pro-Vice Chancellor of the University. During his career he has published over 30 books and 400 papers: his latest book, Essential Biomaterials Science, was published by Cambridge University Press in June 2014. He was Editor-in-Chief of Biomaterials, the world’s leading journal in this field between 2000 and 2014. He has received the major awards from the US, European and Indian societies of biomaterials including the Founders Award of the US Society for Biomaterials in 2007, and received the prestigious Acta Biomaterialia Gold Medal in 2012. In 1999 he was elected as a Fellow of the Royal Academy of Engineering and is a Foreign Fellow of the Indian National Academy of Engineering and a Fellow of the American Institute of Medical and Biological Engineering, all in recognition of his contributions to engineering in medicine. He was global President of the Tissue Engineering & Regenerative Medicine International Society from 2013-2015. He was a scientific advisor to several divisions of the European Commission during the 1990s and wrote several opinions on which European actions were taken. He has, over the last 20 years, given evidence in several major product liability and patent legal cases in the USA, Europe and Australia.

Professor Williams left the University of Liverpool in 2007. While retaining the title of Emeritus Professor at Liverpool, he is currently Professor and Director of International Affairs, Wake Forest Institute of Regenerative Medicine, North Carolina, USA. In addition, he is a Visiting Professor in the Christiaan Barnard Department of Cardiothoracic Surgery, Cape Town, South Africa, a Adjunct Professor at the University of Technology, Sydney, Australia, and a Guest Professor, at Tsinghua University, Beijing, and Advisory Professor at Shanghai Jiao Tong University, China. He is Visiting Chair Professor of Biomedical Materials, Taipei Medical University, Taiwan. In Cape Town, along with Professor Peter Zilla, the current Chris Barnard Professor of Surgery, he has formed a company that will produce low cost but high technology medical devices that can be used with minimally invasive procedures to treat young adults in sub-Sarah Africa, who are suffering from rheumatic heart disease but currently have no therapies available to them.