Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases.
Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases.
Section I. Brain Donor Recruitment Strategies1. The Netherlands
Brain Bank for Psychiatry2. Brain donation procedures in the sudden
death brain bank in Edinburgh
Section II. Brain Bank Networks3. Autism BrainNet 4. The NIH
NeuroBioBank: Creating opportunities for human brain research
Section III. Ethical Aspects of Brain Banking and Management of
Brain Banks5. Design of a European code of conduct for brain
banking6. A review of brain biorepository management and
operations7. A new viewpoint: running a non-profit brain bank as a
business
Section IV. Brain Dissection, Tissue Processing and Tissue
Dissemination8. The New York Brain Bank of Columbia University:
Practical highlights of 35 years of experience9. Neurochemical
markers as potential indicators of post-mortem tissue quality
Section V. Neuropathological Diagnosis10. Minimal neuropathological
diagnosis for brain banking in the normal middle aged and aged
brain and in neurodegenerative disorders 11. Brain donation at
autopsy: Clinical characterization and toxicological analyses
Section VI. Brain Donor Data: Clinical, Genetic, Radiologic and
Research Data Storage and Mining12. Information technology for
brain banking 13. Collecting, storing and mining research data in a
brain bank 14. What can we learn about brain donors? Use of
clinical information in human postmortem brain research15. The art
of matching brain tissue from patients and controls for postmortem
research
Section VII. Human Brain Tissue Analyses: Old and New Techniques16.
Considerations for optimal use of postmortem human brains for
molecular psychiatry: Lessons from schizophrenia17. Epigenetic
analysis of human brain tissue 18. Laser microdissection and gene
expression profiling in the human postmortem brain19. Purification
of cells from fresh human brain tissue: Primary human glial
cells20. Proteomics and lipidomics in the human brain 21. 3-D
imaging in the post-mortem human brain with CLARITY and CUBIC 22.
Neuronal life after death: Electrophysiological recordings from
neurons in adult human brain tissue obtained through surgical
resection or post-mortem23. Post-mortem magnetic resonance
imaging24. Cyto- and receptorarchitectonic mapping of the human
brain25. Mapping pathological circuitry in schizophrenia
Inge Huitinga completed her study Medical Biology in 1988 at the
VUmc in Amsterdam. She obtained her PhD degree on the investigation
of mechanisms of demyelination in multiple sclerosis (MS) cum laude
at the Vrije Universiteit in 1992. Between 1992 and 1999 Inge
continued working on the pathology of MS, part at VUmc, part at the
Netherlands Institute for Neuroscience (NIN) in the group of prof.
Dick Swaab, and part in Oxford, UK. In 1999 she received as the
first the prestigious MS Fellowship of the Stichting MS Research,
to investigate neuronal functioning in MS and was appointed at the
Royal Netherlands Academy of Arts and Science (KNAW). In 2006 she
became director of the Netherlands Brain Bank (NBB) and started her
own Neuroimmunology Research Group and published more than 120
scientific papers on MS with a focus on MS and microglia and
effects of steroid hormones. She professionalized the NBB and
drafted international ethical and
legal guidelines for Brain Banking resulting in a Code of Conduct
for Brain Banking, published in 2015. In 2012 she obtained a
substantial NWO grant of 3.45 M-euro to start a brain bank for
psychiatry within the NBB: NHB-Psy, a national consortium of
NBB/KNAW with 5 Dutch university medical centers to run a brain
donation and autopsy program for 7 psychiatric diseases.Tissue of
these donors are sent to researchers worldwide.
https://nin.nl/research/researchgroups/huitinga-group/
www.brainbank.nl
www.nbb-psy.nl Dr. Maree Jean Webster is from the Stanley Medical
Research Institute, Laboratory of Brain Research, in Rockville,
Maryland, USA.
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