One of the grand challenges in our digital world are the large, complex and often weakly structured data sets, and massive amounts of unstructured information. This "big data" challenge is most evident in biomedical informatics: the trend towards precision medicine has resulted in an explosion in the amount of generated biomedical data sets. Despite the fact that human experts are very good at pattern recognition in dimensions of

Knowledge Discovery and Data Mining in Biomedical Informatics: The Future Is in Integrative, Interactive Machine Learning Solutions.- Visual Data Mining: Effective Exploration of the Biological Universe.- Darwin or Lamarck? Future Challenges in Evolutionary Algorithms for Knowledge Discovery and Data Mining.- On the Generation of Point Cloud Data Sets: Step One in the Knowledge Discovery Process.- Adapted Features and Instance Selection for Improving Co-training.- Knowledge Discovery and Visualization of Clusters for Erythromycin Related Adverse Events in the FDA Drug Adverse Event Reporting System.- On Computationally-Enhanced Visual Analysis of Heterogeneous Data and Its Application in Biomedical Informatics.- A Policy-Based Cleansing and Integration Framework for Labour and Healthcare Data.- Interactive Data Exploration Using Pattern Mining.- Resources for Studying Statistical Analysis of Biomedical Data and R.- A Kernel-Based Framework for Medical Big-Data Analytics.- On Entropy-Based Data Mining.- Sparse Inverse Covariance Estimation for Graph Representation of Feature Structure.- Multi-touch Graph-Based Interaction for Knowledge Discovery on Mobile Devices: State-of-the-Art and Future Challenges.- Intelligent Integrative Knowledge Bases: Bridging Genomics, Integrative Biology and Translational Medicine.- Biomedical Text Mining: State-of-the-Art, Open Problems and Future Challenges.- Protecting Anonymity in Data-Driven Biomedical Science.- Biobanks - A Source of Large Biological Data Sets: Open Problems and Future Challenges.- On Topological Data Mining.