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Leading gender and science scholar Sarah S. Richardson charts the untold history of the idea that a woman’s health and behavior during pregnancy can have long-term effects on her descendants’ health and welfare.
The idea that a woman may leave a biological trace on her gestating offspring has long been a commonplace folk intuition and a matter of scientific intrigue, but the form of that idea—and its staggering implications for maternal well-being and reproductive autonomy—has changed dramatically over time. Beginning with the advent of modern genetics at the turn of the twentieth century, biomedical scientists dismissed any notion that a mother—except in cases of extreme deprivation or injury—could alter her offspring’s traits. Consensus asserted that a child’s fate was set by a combination of its genes and post-birth upbringing.
Over the last fifty years, however, this consensus was dismantled, and today, research on the intrauterine environment and its effects on the fetus is emerging as a robust program of study in medicine, public health, psychology, evolutionary biology, and genomics. Collectively, these sciences argue that a woman’s experiences, behaviors, and physiology can have life-altering effects on offspring development. Tracing a genealogy of ideas about heredity and maternal-fetal effects, The Maternal Imprint offers a critical analysis of conceptual and ethical issues provoked by the striking rise of epigenetics and fetal origins science in postgenomic biology today.
Leading gender and science scholar Sarah S. Richardson charts the untold history of the idea that a woman’s health and behavior during pregnancy can have long-term effects on her descendants’ health and welfare.
The idea that a woman may leave a biological trace on her gestating offspring has long been a commonplace folk intuition and a matter of scientific intrigue, but the form of that idea—and its staggering implications for maternal well-being and reproductive autonomy—has changed dramatically over time. Beginning with the advent of modern genetics at the turn of the twentieth century, biomedical scientists dismissed any notion that a mother—except in cases of extreme deprivation or injury—could alter her offspring’s traits. Consensus asserted that a child’s fate was set by a combination of its genes and post-birth upbringing.
Over the last fifty years, however, this consensus was dismantled, and today, research on the intrauterine environment and its effects on the fetus is emerging as a robust program of study in medicine, public health, psychology, evolutionary biology, and genomics. Collectively, these sciences argue that a woman’s experiences, behaviors, and physiology can have life-altering effects on offspring development. Tracing a genealogy of ideas about heredity and maternal-fetal effects, The Maternal Imprint offers a critical analysis of conceptual and ethical issues provoked by the striking rise of epigenetics and fetal origins science in postgenomic biology today.
1. Introduction: The Maternal Imprint
2. Sex Equality in Heredity
3. Prenatal Culture
4. Germ Plasm Hygiene
5. Maternal Effects
6. Race, Birth Weight, and the Biosocial Body
7. Fetal Programming
8. It’s the Mother!
9. Epilogue: Gender and Heredity in the Postgenomic Moment
Acknowledgments
Notes
References
Index
Sarah S. Richardson is professor of the history of science and of studies of women, gender, and sexuality at Harvard University. She directs the Harvard GenderSci Lab and is the author of Sex Itself: The Search for Male and Female in the Human Genome, also published by the University of Chicago Press.
"An outstanding depiction of the mutual constitution of science and
society. Cleverly unpacking the complex history of scientific
debates on so-called 'maternal impressions' (later, 'maternal
effects') on offspring and future generations, author Sarah
Richardson unveils the epistemological origins of concepts we take
for granted today. . . . The book is an epistemological
provocation, a reminder that science is a political enterprise, and
an invitation to produce knowledge that empowers women instead of
knowledge that makes them solely responsible for our collective
future."
*Science*
"[A] rigorous academic study... Policymakers, health-care
providers, and scientific researchers will want to take note."
*Publishers Weekly*
“Sarah Richardson’s book The Maternal Imprint… argues that
social assumptions about maternal responsibility lend ideas in this
field more credibility than they deserve on the basis of the data.
Her argument will be interesting to researchers, pregnant nerds and
policymakers.”
*Nature*
"Richardson explains and challenges much of what I (and probably
you) take for granted about human pregnancy and the role of mothers
in fetal development. Richardson
brilliantly confronts notions that some women are 'bad mothers' who
imperil the welfare of their offspring by not taking care of
themselves sufficiently while pregnant. . . . The Maternal
Imprint is a thoroughly researched, amusing, and confronting
book that should be essential reading for anyone interested in
epigenetics, infant health, and how these interact with race and
social class."
*FASEB Journal*
"Enlightening. . . . What is particularly compelling about
Richardson's approach is that by situating the field’s challenges
in a broader social and historical context, we get a sense of why
they matter. . . . In the likelihood that epigenetics might be used
to explore the long shadow of our current trauma, Richardson's book
offers an important lens through which we can regard claims
about the role of maternal bodies."
*Lancet*
"The inheritance of acquired traits is not a heresy in medicine,
but the basis of an enormously productive research
program... Richardson puts this research in its historical
context and takes a critical look at its basic assumptions, methods
and conclusions."
*Archyde*
"In this volume, historian and philosopher of science Richardson...
provides a historical overview and an analysis of debates,
theories, and research about epigenetics and gene expression,
spanning from Weismann’s expression of deterministic germ plasma
theory in the late 19th century to current epigenetics and theory
about the developmental origins of health and disease as
articulated in the early 21st century."
*CHOICE*
"Beliefs about which specific maternal behaviors or experiences
have lasting effects on gestating offspring have shifted widely
over time. . . . [Richardson] gives this rich history a
clearer context in the discussion of reproductive
responsibility."
*Harvard Gazette*
"Richardson concisely and vividly presents how medical and
scientific thinking about the contribution of mothers and fathers
to the development of offspring developed. Richardson's thoroughly
compelling book . . . shows the ideological complexity of modern
science."
*Frankfurter Allgemeine Zeitung*
"The Maternal Imprint will be of interest to a trans-disciplinary
audience in that it provides a historical critique of science
that is well-versed in the scientific claims and attuned to
the influence of culture on science. This trans-disciplinary book
provides a framework for both biological and social scientists to
think about the values and assumptions that have guided their
disciplines' perspectives on the maternal body and infant
health."
*Metascience*
“[Richardson’s] compelling interpretation cleanly cuts through the
posited difference between genetics and epigenetics, ‘hard’ and
‘soft’ heredity. Far from challenging genetic determinism,
epigenetic pregnancy research ‘advances a model of human
inheritance and development in which the wider social and physical
environment can be seen as heritable and as determinant of future
biomedical outcomes.’ Constructions of epigenetics as bridging the
gap between social and biological processes resonate widely in STS
and gender studies, even among critical scholars; Richardson’s book
is a thought-provoking intervention.”
*Isis*
“Richardson’s book is rigorous, entertaining, informative, and
politically important.”
*Kennedy Institute of Ethics Journal*
“Academically robust and meticulously researched, The Maternal
Imprint is a pleasurable and engaging read that will appeal to a
wide audience, including the public and undergraduate
students.”
*Childhood in the Past*
"A rich, elegantly argued analysis of the long history of
scientific and popular thinking about 'maternal effects' on the
fetuses that women gestate, full of well-articulated plunges into
the archives of scientific texts and journals in the nineteenth and
twentieth centuries. This is an important, beautifully researched,
and well-written book by an author whose prior works have literally
changed their fields."
*Rayna Rapp, New York University*
"Richardson reveals that epigenetics is not just the newest
cutting-edge, pro-social, plasticity-favoring, anti-genetic, and
anti-reductionist field to emerge from modern molecular genetics.
Rather, it is also the vector of newly problematic images and
social roles that limit women and diminish the status of pregnancy
and motherhood, in ways that are disturbingly similar to
nineteenth-century societal notions of women's roles. Richardson's
exquisitely documented arguments will be compelling to all with an
interest in the complex interface of science and society."
*Michael J. Wade, Indiana University*
"This is a major contribution from a feminist STS scholar who
deftly interweaves scientific, epistemological, and ethical
considerations into a tour-de-force book on a topic with
implications for mothers, families, and communities."
*Alexandra Minna Stern, author of Eugenic Nation: Faults and
Frontiers of Better Breeding in Modern America*
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