In some form, risk management (RM) has always been an integral part of virtually every challenging human endeavor. A formal and, at that time, qualitative RM process known as Continuous Risk Management (CRM) was introduced to NASA in the latter half of the 1990s. More rigorous quantitative RM processes including Risk-Informed Decision Making (RIDM) and an enhanced version of CRM have only recently been developed for implementation as an integral part of systems engineering at NASA. While there will probably always be vigorous debate over the details of what comprises the best approach to managing risk, few will disagree that effective risk management is critical to program and project success and affordability. Since their introduction and until recently, NASA RM processes have been based on CRM, which stresses the management of risk during the Implementation phase of the NASA Program Project Life Cycle. In December of 2008, NASA issued NPR 8000.4A, which introduced RIDM as a complementary process to CRM that is concerned with analysis of important and or direction-setting decisions. In the past, RM was considered equivalent to CRM; now, RM is defined as comprising both CRM and RIDM. In April 2010, NASA issued NASA SP-2010-576, the NASA Risk-Informed Decision Making Handbook. This handbook introduced RIDM as the front-end of the RM process, described the details of how RIDM is conducted, and ended with a description of how the results of RIDM transition to and set the stage for CRM, the final portion of the RM process. The RIDM Handbook did not proceed to describe CRM, as the development of an enhanced version of CRM was still a work in progress in 2010. Now this handbook addresses the entirety of the NASA RM process, including both RIDM and CRM. The purpose of this handbook is to provide guidance for implementing the Risk Management (RM) requirements of NASA Procedural Requirements (NPR) document NPR 8000.4A, Agency Risk Management Procedural Requirements, with a specific focus on programs and projects, and applying to each level of the NASA organizational hierarchy as requirements flow down. This handbook supports RM application within the NASA systems engineering process, and is a complement to the guidance contained in NASA SP-2007-6105, NASA Systems Engineering Handbook. Specifically, this handbook provides guidance that is applicable to the common technical processes of Technical Risk Management and Decision Analysis established by NPR 7123.1A, NASA Systems Engineering Process and Requirements. These processes are part of the Systems Engineering Engine that is used to drive the development of the system and associated work products to satisfy stakeholder expectations in all mission execution domains, including safety, technical, cost, and schedule.