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A fully updated and expanded edition of the bestselling guide on toxicology and its practical application
* Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards
* New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology
* Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems
* Includes case histories and examples from industry demonstrate the application of toxicological principles
* Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms
A fully updated and expanded edition of the bestselling guide on toxicology and its practical application
* Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards
* New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology
* Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems
* Includes case histories and examples from industry demonstrate the application of toxicological principles
* Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms
Contributors vii
Preface ix
1 General Principles of Toxicology 1
Robert C. James, Stephen M. Roberts, and Phillip L. Williams
2 Xenobiotic Absorption, Distribution, Metabolism, and Excretion
29
Michael R. Franklin
3 Toxicokinetics 59
Rebecca A. Clewell and Harvey J. Clewell III
4 Omics Technologies in Toxicology 89
Mary Jane Cunningham
5 Toxicity of the Hematopoietic System 103
Sherilyn A. Gross
6 Hepatotoxicity: Toxic Effects on the Liver 125
Robert C. James and Stephen M. Roberts
7 Nephrotoxicity: Toxic Responses of the Kidney 139
Lawrence H. Lash
8 Neurotoxicity: Toxic Effects on the Nervous System 157
William M. Caudle and Gary W. Miller
9 Dermatotoxicity: Toxic Effects on the Skin 169
Sailesh Konda and Howard I. Maibach
10 Pulmonotoxicity: Toxic Effects in the Lung 179
Cuiqing Liu and Qinghua Sun
11 Immunotoxicity: Toxic Effects on the Immune System 197
Eric S. Sobel and Stephen M. Roberts
12 Toxic Effects on Reproduction 211
Mary L. Hixon
13 Developmental Toxicology 223
Vincent F. Garry and Peter L. Truran
14 Mutagenesis and Genetic Toxicology 235
Martha M. Moore, Meagan B. Myers, and Robert H. Heflich
15 Chemical Carcinogenesis 259
James E. Klaunig
16 Properties and Effects of Metals 283
David B. Mayfield, Ari S. Lewis, Lisa A. Bailey, and Barbara D.
Beck
17 Properties and Effects of Pesticides 309
Janice Britt
18 Properties and Effects of Solvents and Solvent-Like Chemicals
325
Christopher M. Teaf, Michele M. Garber, and J. Michael
Kuperberg
19 Nanotoxicology 359
Hongbo Ma, Steve Diamond, Georgia Hinkley, and Stephen M.
Roberts
20 Computational Toxicology 373
Richard S. Judson, David M. Reif, and Keith A. Houck
21 E pidemiological Issues in Occupational and Environmental
Health 391
Michael S. Bloom and John E. Vena
22 Occupational and Environmental Health 411
Brenda S. Buikema, T. Renée Anthony, and Fredric Gerr
23 Human Health Risk Assessment 425
Leah D. Stuchal, Robert C. James, and Stephen M. Roberts
Glossary 457
Index 471
Stephen M. Roberts, PhD, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville Robert C. James, PhD, is Senior Principal Scientisst, ToxStrategies, Inc., Tallahassee, Florida, and Associate Scientist at the Center for Environmental and Human Toxicology at the University of Florida, Gainesville Phillip L. Williams, PhD, is Dean & Georgia Power Professor at the University of Georgia, Athens
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