A unique book on diagnosis, consequences and management of neonatal and infantile seizures. There is a very high incidence of seizures during the first two years of life. This may reflect multiple etiologies depending on the circumstances under which seizures occur; seizures may lead to or herald epilepsy. Within this period there is the frequent onset of difficult to control epilepsy with often devastating consequences (i.e. West syndrome or Dravet syndrome), although on other occasions the epileptic syndromes may have a more benign cause (i.e. benign familial neonatal seizures). Ongoing efforts are to understand : 1. How seizures may occur in the developing brain? 2. What are their consequences? 3. Which biomarkers are being developed? 4. What are the effective treatments to promptly stop ongoing seizures and alter the course of epileptic encephalopathies? The topics presented in this volume address the questions raised above, and provide new insights on how it is best to approach seizures and epilepsy in the first two years of life, to systematically create a blueprint upon which diagnostic and treatment decisions can be based. The data are highly reflecting the state of the art and also individualize for the particular milieu of the patient in taking into account both nature, and nurture and result in seizures and epilepsy.
A unique book on diagnosis, consequences and management of neonatal and infantile seizures. There is a very high incidence of seizures during the first two years of life. This may reflect multiple etiologies depending on the circumstances under which seizures occur; seizures may lead to or herald epilepsy. Within this period there is the frequent onset of difficult to control epilepsy with often devastating consequences (i.e. West syndrome or Dravet syndrome), although on other occasions the epileptic syndromes may have a more benign cause (i.e. benign familial neonatal seizures). Ongoing efforts are to understand : 1. How seizures may occur in the developing brain? 2. What are their consequences? 3. Which biomarkers are being developed? 4. What are the effective treatments to promptly stop ongoing seizures and alter the course of epileptic encephalopathies? The topics presented in this volume address the questions raised above, and provide new insights on how it is best to approach seizures and epilepsy in the first two years of life, to systematically create a blueprint upon which diagnostic and treatment decisions can be based. The data are highly reflecting the state of the art and also individualize for the particular milieu of the patient in taking into account both nature, and nurture and result in seizures and epilepsy.
Preface; Foundations of Neonatal Epileptology: Classification of Seizures & Epilepsies in the Neonate & their Etiology, Electroencephalography, Prognosis & Pathophysiology; EEG Monitoring in Neonatal Seizures: What is Done, What Could Be Done?; Neuro-Imaging in Neonatal Seizures; Clinical & Electrographical Neonatal Seizures: to Treat or Not to Treat; Genetics of Neonatal Epilepsies & the Forgotten Epilepsy Phenotypes; Genetic Basis of Epileptic Encephalopathy; Treatment of Neonatal Seizures With Antiepileptic Drugs; Neonatal Seizures in Hypoxic-Ischaemic Encephalopathy: The Impact of Therapeutic Hypothermia; From Conventional Genetic Analysis to Next Generation Sequencing in Diagnostics of Epilepsies; Treatable New-born Seizures Due to Inborn Errors of Metabolism; Determining Outcome from Neonatal Seizures; The Epidemiology of Infancy Onset Seizures; Concept of Epileptic Encephalopathy: Is it Relevant?; The Role of EEG in the Management of Seizures in Infancy; Optimizing Imaging in Aiding Management; "Benign" Epilepsies in Infants: Are They Always Benign?; Fever-Susceptibility Syndromes. Predicting Outcome; Infantile Spasms Semiology & Pathophysiology: Have We Made Progress?; Trials for the Treatment of Infant Seizures: Theory, Practice, Ethics & Potential Future Trends; The Role of Ketogenic Diet; Optimizing Treatment for Neonatal & Infantile Seizures: Do Guidelines Have a Role in Management?
J. Helen Cross, The Prince of Wales's Chair of Childhood Epilepsy, Deputy Head of Developmental Neurosciences Programme, Great Ormond Street Hospital, Institute of Child Health, London, UK.
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