It's barely 40 years ago that James Watson and Francis Crick discovered the code of law that governs inheritance, the base-pairing rules of DNA. Since then, there has been an explosion of knowledge: scientists can now manipulate DNA to correct a damaged cell, nurture an endangered embryo, arrest degenerative diseases, detect foetal chromosome abnormalities and even secure convictions by genetic fingerprinting. The underlying potential of such a powerful knowledge creates grounds for an explosive ethical and legal debate.
It's barely 40 years ago that James Watson and Francis Crick discovered the code of law that governs inheritance, the base-pairing rules of DNA. Since then, there has been an explosion of knowledge: scientists can now manipulate DNA to correct a damaged cell, nurture an endangered embryo, arrest degenerative diseases, detect foetal chromosome abnormalities and even secure convictions by genetic fingerprinting. The underlying potential of such a powerful knowledge creates grounds for an explosive ethical and legal debate.
Invisible cities and crystalline books; chromosomes and canons; sentences, sculptures and the ambiguities of translation; the molecular word processor; texts, contexts and the transgenic stage; between physics and history - the new paradigm of biology.
Pollack, who was a protege of James Watson at Cold Spring Harbor Lab in New York, utilizes his position as a first-generation molecular geneticist as both lectern and pulpit. His state-of-the-genome report, based on the metaphor of genes as ``text'' has a smooth style which lends an authoritative background to his Faustian warning that genetics is the crossroads of science and society. He attempts to elucidate the workings of DNA, explores the significance of our ability to change the human genome and emphasizes the consequences of DNA mastery. Pollack acknowledges that his warning about the perils of this new knowledge is really writing on the bones of an older theme explored by Shelley, Goethe and H. G. Wells. His accessible model of the state of the discipline is informed by an energetic humanity, making for a challenging look at a front-page science topic. (Jan.)
Nowhere are the frontiers of modern science expanding more rapidly than in the field of molecular biology. Some of the new discoveries in the workings of DNA and genome sequencing not only offer the promise of opening new thresholds of understanding but also raise unprecedented questions about the fundamental nature of life and being human. Biologist Pollack argues that DNA can be read almost like a work of great literature. In expounding that view, he uses a uniquely literate and metaphorical style of popular science writing. Robert Shapiro's The Human Blueprint ( LJ 9/1/91) covers much the same territory and more, but Pollack's very personal and readable prose may have more appeal to general readers. Previewed in Prepub Alert, LJ 9/1/93.-- Gregg Sapp, Montana State Univ. Libs., Bozeman
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