The detection of single molecules opens up new horizons in analytical chemistry, biology and medicine. This discipline, which belongs to the expanding field of nanoscience, has been rapidly emerging over the last ten years. This handbook provides a thorough overview of the field. It begins with basics of single molecule detection in solution, describes methods and devices (fluorescense correlation spectroscopy, surface enhanced Raman scattering, sensors, especially dyes, screening techniques, especially confocal laser scanning microscopy). In the second part, various applications in life sciences and medicine provide the latest research results. This modern handbook is a highly accessible reference for a broad community from advanced researchers, specialists and company professionals in physics, spectroscopy, biotechnology, analytical chemistry, and medicine. Written by leading authorities in the field, it is timely and fills a gap - up to now there exists no handbook concerning this theme.
The detection of single molecules opens up new horizons in analytical chemistry, biology and medicine. This discipline, which belongs to the expanding field of nanoscience, has been rapidly emerging over the last ten years. This handbook provides a thorough overview of the field. It begins with basics of single molecule detection in solution, describes methods and devices (fluorescense correlation spectroscopy, surface enhanced Raman scattering, sensors, especially dyes, screening techniques, especially confocal laser scanning microscopy). In the second part, various applications in life sciences and medicine provide the latest research results. This modern handbook is a highly accessible reference for a broad community from advanced researchers, specialists and company professionals in physics, spectroscopy, biotechnology, analytical chemistry, and medicine. Written by leading authorities in the field, it is timely and fills a gap - up to now there exists no handbook concerning this theme.
INTRODUCTION Theoretical Foundations of Single Molecule Detection in Solution METHODS OF SINGLE MOLECULE DETECTION Conceptual Basis of Fluorescence Correlation Spectroscopy and Related Techniques as Tools in Bioscience Surface-enhanced Raman scattering (SERS) - a tool for single molecule detection in solution Single molecule detection on surfaces with the confocal laser scanning microscope APPLICATIONS OF SINGLE MOLECULE DETECTION Spectroscopy of Individual Photosynthetic Pigment Protein Complexes Single Dye Tracing for Ultrasensitive Microscopy on Living Cells Single Molecule Identification in Solution: Principles and Applications Studying molecular motors on single molecule level The chemistry of a single enzyme molecule Single Molecule Detection of Specific Nucleic Acid Sequences Single Molecule Detection in the Near-Infrared
Well known international researchers and specialists from USA, Canada, Germany, Netherlands S.A. Soper is editor of "Single Molecules", Wiley-VCH Boehmer, Martin (University of Regensburg, Germany) Castro, Alonso (Los Alamos National Laboratory, NM, USA) Dovichi. N. J. (University of Alberta, Canada) Enderlein, Joerg (University of Regensburg, Germany) Keller, Richard A. (Los Alamos National Laboratory, NM, USA) Kneipp, Katrin (M.I.T., MA, USA) Koehler, Juergen (Ludwig Maximilians University of Munich, Germany) Nie, Shuming (University of Bloomington, IN, USA) Sauer, Markus (University of Heidelberg, Germany) Schmidt, Thomas (University of Leiden, The Netherlands) Soper, Steve A. (Louisiana State University, LA, USA) Thiel, Erwin (University of Siegen, Germany) Wrachtrup, Joerg (Technical University of Chemnitz, Germany) Yanagida, Toshio (Osaka University, Japan) Zander, Christoph (University of Siegen, Germany)
"Single-molecule detection and the field of nanoscience have expanded during the past 10 years. This book covers the gambit..." (Analytical Chemistry, November 2002)
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