This comprehensive reference explores-from the perspective of regenerative medicine and tissue engineering-the body's ability to mobilize endogenous stem cells to the site of injury plus the latest strategies for inducing and supporting the body's own regenerating capacity
1. Fundamentals of In Situ Tissue Regeneration Sang Jin Lee, James
J. Yoo and Antony Atala 2. Stem Cell Homing Mariusz Z. Ratajczak
and Ahmed A. Ismail 3. Immunology – Host Responses to Biomaterials
John D. Jackson
4. Foreign Body Reaction and Stem Cell Responses Ashwin Nair and
Liping Tang
5. Roles of endogenous growth factors and small peptides in
in situ tissue regeneration Suna Kim, Hyun Sook Hong and Youngsook
Son
6. Small molecules: Controlling cell fate and function Baisong Lu
and Anthony Atala
7. Small RNA Delivery for In Situ Tissue Regeneration NaJung Kim,
James J. Yoo, Anthony Atala, and Sang Jin Lee 8. Micro and Nano
Topographical cues guiding biomaterial host response Deepak M.
Kalaskar and Feras Alshomer
9. Mechanobiology and Mechanotherapy in Tissue Engineering Rei
Ogawa
10. A biomimetic strategy to design biomaterials for in situ tissue
regeneration Ji Hyun Kim and Sang Jin Lee
11. Impact of Matrix Dynamic Properties on Stem Cell Viability Marc
B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and
Yihua B. Yu
12. Cell-free Scaffolds for In situ Tissue Regeneration Seung Hun
Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim
13. In Situ Tissue Regeneration: Host Cell Recruitment and
Biomaterial Design T. Konrad Rajab and Harald Ott
14. Synovial Joint: In Situ Regeneration of Osteochondral and
Fibrocartilaginous Tissues by Homing of Endogenous Cells Solaiman
Tarafder and Chang H. Lee
15. Bioengineered strategies for tendon regeneration Ana I.
Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E.
Gomes
16. Volumetric Muscle Repair In Situ Lindsey E. Shapiroa, Ji Hyun
Kima, In Kap Ko, Sang Jin Lee, James J. Yoo and Anthony
Atalaa
17. Mending The Heart Through In Situ Cardiac Regeneration Jeremy
Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab
and Nicolas Christoforou
18. Skin Wound Healing – Skin Regeneration with Pharmacological
Mobilized Stem Cells Zhaoli Sun and George Melville Williams
19. In situ renal regeneration Hung-Jen Wang, Sang Jin Lee, Anthony
Atala and James J. Yoo
20. Regulatory Aspects: regulation aspects of cell-free biomaterial
implants Nan Zhang, Alexander Baume, Richard Payne, Julie
Allickson
21. Business Perspective – case study: commercialized
cell-free cardiovascular implant Alexander Sheehy, Byron Lambert
and Richard Rapoza
Dr. Lee has extensive knowledge and experience in biomaterials
science, especially, biodegradable polymers and tunable hydrogels,
with specific training and expertise in key research areas for
tissue engineering and regenerative medicine. His research team has
developed various biomaterial systems that improve cellular
interactions by providing appropriate environmental cues. Dr. Lee’s
research team also demonstrated the principle of “in situ tissue
regeneration that is to take advantage of the body’s own
regenerating capacity by using the host's ability to mobilize
endogenous stem cells to the site of injury. Currently, his
research has focused on development of strategies for in situ
tissue regeneration in terms of mechanism of host cell recruitment,
cell sourcing, cellular and molecular roles in cell
differentiation, navigational cues and niche signals, and a
tissue-specific smart biomaterial system from the perspective of
regenerative medicine and tissue engineering. Anthony Atala, MD, is
the G. Link Professor and Director of the Wake Forest Institute for
Regenerative Medicine, and the W. Boyce Professor and Chair of
Urology. Dr. Atala is a practicing surgeon and a researcher in the
area of regenerative medicine. Fifteen applications of technologies
developed in Dr. Atala's laboratory have been used clinically. He
is Editor of 25 books and 3 journals. Dr. Atala has published over
800 journal articles and has received over 250 national and
international patents. Dr. Atala was elected to the Institute of
Medicine of the National Academies of Sciences, to the National
Academy of Inventors as a Charter Fellow, and to the American
Institute for Medical and Biological Engineering.
Dr. Atala has led or served several national professional and
government committees, including the National Institutes of Health
working group on Cells and Developmental Biology, the National
Institutes of Health Bioengineering Consortium, and the National
Cancer Institute’s Advisory Board. He is a founding member of the
Tissue Engineering Society, Regenerative Medicine Foundation,
Regenerative Medicine Manufacturing Innovation Consortium,
Regenerative Medicine Development Organization, and Regenerative
Medicine Manufacturing Society. Professor, Wake Forest Institute
for Regenerative Medicine, Winston-Salem, NC
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