It's a new semester for child prodigy Sheldon Cooper and a year of upheaval for the entire Cooper family. Sheldon attends his firs comic convention, gets his first set of nerdy friends and fails to impress his first engineering professor. George Sr and Mary face conflicts at work and struggles in their marriage. Missy questions her religious beliefs and asks some uncomfortable questions about sex. Meemaw buys a laundromat with a secret gambling room and hires Georgie as her new manager. And Georgie's relationship with an older woman leads to a life-changing decision.